P. mirabilis has a bacillus morphology and is a gram-negative bacterium. It is motile, alternating between vegetative swimmers and hyper-flagellated swarmer cells (Belas, 1996). It also makes a variety of fimbriae.
Lot more interesting detail can be read here. In this way, what is the shape of Proteus mirabilis?
Proteus mirabilis is a Gram-negative, facultatively anaerobic, rod-shaped bacterium. It shows swarming motility and urease activity. P. mirabilis causes 90% of all Proteus infections in humans.
Also Know, is Proteus mirabilis dangerous? Proteus is found abundantly in soil and water, and although it is part of the normal human intestinal flora (along with Klebsiella species, and Escherichia coli), it has been known to cause serious infections in humans.
where does Proteus mirabilis come from?
Proteus mirabilis is part of the normal flora of the human gastrointestinal tract. It can also be found free living in water and soil. When this organism, however, enters the urinary tract, wounds, or the lungs it can become pathogenic.
What Antibiotics kill Proteus mirabilis?
The most appropriate treatment for P. mirabilis may be aminoglycosides, carbapenems (except imipenem), and 3rd generation cephalosporins. Recent P. mirabilis isolates were also mostly susceptible to augmentin, ampicillin-sulbactam, and piperacillin/tazobactam.
How do I know if I have Proteus mirabilis?
Diagnosis. An alkaline urine sample is a possible sign of P. mirabilis. It can be diagnosed in the lab due to characteristic swarming motility, and inability to metabolize lactose (on a MacConkey agar plate, for example).
What does Proteus mirabilis smell like?
Proteus Mirabilis. A surprisingly common cause of UTIs. It smells like old garbage when grown on agar plates, although others claim it smells like burnt chocolate or cocoa.
How do you get Proteus infection?
Infection occurs either by migration of bacteria up the catheter along the mucosal sheath or by migration up the catheter lumen from infected urine. UTIs are the most common clinical manifestation of Proteus infections.
What are the symptoms of Proteus infection?
They include dysuria, increased frequency, urgency, suprapubic pain, back pain, small volumes, concentrated appearance, and hematuria. If the patient is febrile, this could be a sign of bacteremia and impending sepsis. These symptoms may not be present if the patient has an indwelling catheter.
How is Proteus mirabilis different from Proteus vulgaris?
Proteus mirabilis (indole negative) is the most frequent Proteus species associated with urinary tract infections, but indole-positive Proteus species like Pr. vulgaris, which are more often resistant to ampicillin, may also cause urinary tract infections. These species are often associated with an alkaline urine.
Can Proteus mirabilis cause kidney stones?
Infection with P. mirabilis tends to result in unique kidney pathology. For instance, P. mirabilis is the only species that causes a high incidence of kidney stone formation in a rat model of pyelonephritis (59), and it causes more kidney stones and greater kidney damage than other urease-positive organisms such as P.
Is Proteus mirabilis difficult to treat?
Proteus is a particularly toxic, difficult-to treat bacterium that can become resistant to antibiotics. Proteus produces the enzyme urease, which can reduce the acidity of the urine, allowing stones to form.
Where is Proteus found?
Proteus species are most commonly found in the human intestinal tract as part of normal human intestinal flora, along with Escherichia coli and Klebsiella species, of which E coli is the predominant resident. Proteus is also found in multiple environmental habitats, including long-term care facilities and hospitals.
What is meant by Proteus?
In Greek mythology, Proteus (/ˈpro?ti?s, -tjuːs/; Ancient Greek: Πρωτεύς) is an early prophetic sea-god or god of rivers and oceanic bodies of water, one of several deities whom Homer calls the “Old Man of the Sea” (halios gerôn).
Does Keflex treat Proteus mirabilis?
KEFLEX is indicated for the treatment of genitourinary tract infections, including acute prostatitis, caused by susceptible isolates of Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
How can Proteus vulgaris be transmitted?
MODE OF TRANSMISSION: Proteus spp. are part of the human intestinal flora 1, 3– 5 and can cause infection upon leaving this location. They may also be transmitted through contaminated catheters (particularly urinary catheters) 1, 4, 5 or by accidental parenteral inoculation.
How is Proteus mirabilis transmitted?
Proteus mirabilis can enter the bloodstream through wounds. This happens with contact between the wound and an infected surface. The bacteria induce inflammatory response that can cause sepsis and systemic inflammatory response syndrome (SIRS).